Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

Masanori Inaba, Tatsuya Sakai, Shun Shinada, Tsuyuka Sugiishi, Yuta Nishina, Norio Shibata, Hideki Amii

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramolecular cyclization to give perfluoroalkylphthalides in good yields.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalBeilstein Journal of Organic Chemistry
Publication statusPublished - Jan 19 2017


  • Cyclization
  • Fluorine
  • Lactone
  • Phthalide
  • Trifluoromethylation

ASJC Scopus subject areas

  • Organic Chemistry


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