On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon

Kazuhiro Nakanishi, Takaharu Sakiyama, Koreyoshi Imamura

Research output: Contribution to journalReview articlepeer-review

883 Citations (Scopus)


Adsorption of proteins on solid surfaces and their interaction are major concerns in a number of fields such as biology, medicine, biotechnology and food processing, and play an important role from various points of view. Based on practical viewpoints, information on the conformation of the adsorbed protein as well as adsorption characteristics is essential for a system's performance. Although there are still many problems to be solved, extensive studies in recent years, owing to the development in instrumentation and instrumental techniques, reveal the adsorption behavior of proteins in detail. Here, we stress the importance and interesting aspect of protein adsorption on solid surfaces by reviewing findings that have been obtained in recent years.

Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalJournal of Bioscience and Bioengineering
Issue number3
Publication statusPublished - Jan 1 2001


  • Adsorption
  • Amino acid
  • Conformational change
  • Enzyme
  • Peptide
  • Protein

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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