Oncocytic carcinoma of the submandibular gland: A case report and literature review

Michihiro Nakada, Kazunori Nishizaki, Hirofumi Akagi, Yu Masuda, Tadashi Yoshino

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44 Citations (Scopus)


Oncocytes are characterized by a remarkable number of mitochondria as demonstrated by electron microscopy. Oncocytomas are very rare tumors that are usually benign and typically occur in the parotid gland. Oncocytic carcinomas are exceedingly rare in the salivary glands. We describe a 69-year-old Japanese man with an oncocytic carcinoma of the submandibular gland. We reviewed 38 articles describing oncocytic carcinoma of the head and neck that included clinicopathologic features. Oncocytic carcinomas appear to arise from benign oncocytomas, or may also arise de novo. In oncocytic carcinoma of the head and neck, the presence of distant, rather than local lymph node, metastasis is the most important prognostic indicator.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
JournalJournal of Oral Pathology and Medicine
Issue number5
Publication statusPublished - May 1 1998


  • Mitochondria
  • Oncocyte
  • Oncocytic carcinoma
  • Oncocytoma
  • Submandibular gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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