One-pot construction of 3,3′-bisindolylmethanes through Bartoli indole synthesis

Takumi Abe, Shuuhei Nakamura, Reiko Yanada, Tominari Choshi, Satoshi Hibino, Minoru Ishikura

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


A one-pot approach to 3,3′-bisindolylmethane derivatives from nitrobenzene derivatives through the Bartoli indole synthesis was developed, in which the acid used to quench the reaction markedly affected its outcome. Quenching the reaction with concd HCl produced 3,3′-bisindolylmethane in contrast to the formation of 7-substituted indole by quenching with NH 4Cl.

Original languageEnglish
Pages (from-to)3622-3625
Number of pages4
JournalOrganic Letters
Issue number14
Publication statusPublished - Jul 19 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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