Open-air and solvent-free ester condensation catalyzed by sulfonic acids

Akira Sakakura, Yoshiki Koshikari, Kazuaki Ishihara

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Ester condensation is one among the most fundamental organic transformations, and more environmentally benign alternatives to current esterification processes are needed. Under solvent-free and drying agent-free conditions, catalytic amounts of sulfonic acids promote ester condensation between an equimolar mixture of carboxylic acids and alcohols. In particular, p-toluenesulfonic acid (TsOH) and 10-camphorsulfonic acid (CSA), which have appropriate acidities, efficiently catalyze the ester condensation of secondary alcohols without their decomposition. Since the present protocol does not require solvents under simple open-air conditions, a large amount of esters can be synthesized in a rather small apparatus.

Original languageEnglish
Pages (from-to)5017-5020
Number of pages4
JournalTetrahedron Letters
Issue number34
Publication statusPublished - Aug 18 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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