Oral administration of tritiated water (HTO) in mouse. II. Tumour development

O. Yamamoto, T. Seyama, T. Jo, H. Terato, T. Saito, A. Kinomura

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22 Citations (Scopus)


Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalInternational Journal of Radiation Biology
Issue number1
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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