Organic–inorganic nanocrystal reductase to promote green asymmetric synthesis

Kotchakorn T.sriwong, Afifa Ayu Koesoema, Tomoko Matsuda

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    An acetophenone reductase from Geotrichum candidum (GcAPRD) was immobilized by the organic–inorganic nanocrystal method. The GcAPRD nanocrystal presented improved stability and recyclability compared with those of the free GcAPRD. Moreover, the GcAPRD nanocrystal reduced broad kinds of ketones with excellent enantioselectivities to produce beneficial chiral alcohols such as (S)-1-(3′,4′-dichlorophenyl)ethanol with >99% yield and >99% ee. The robust and versatile properties of the GcAPRD nanocrystal demonstrated an approach to promote green asymmetric synthesis and sustainable chemistry.
    Original languageEnglish
    Pages (from-to)30953-30960
    Number of pages8
    JournalRSC Adv.
    Issue number51
    Publication statusPublished - 2020


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