Original: Periodontal Tissue Reaction to Mechanical Stress in Mice

Takehiro Watanabe, Norimasa Okafuji, Keisuke Nakano, Rina Muraoka, Kazuhiro Yamada, Toshiyuki Kawakami, Toshiyuki Kawakami, Takako Shimizu, Saburo Kurihara

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


In this paper, we examined the periodontal tissue reaction course of mice to mechanical stress according to the Waldo method, before examination of the transcription factor profile change. In the examination group, the arrangement of the periodontal ligament was irregular on specimen day 1. The extension and compression sites were observed at the opposite side of the roots. In day 1 and 3 specimens, the osteoclasts appeared in the compression sites. In day 7 specimens, the number of osteoclasts was reduced in number to less than that of day 3. Immunohistochemical examination revealed that the expression patterns of Runx2 and Msx2 were clearly dynamic changed compared to the control specimens. These results suggest that the appearance of transcription factors related to cell differentiation of periodontal ligament, which was due to the mechanical stress of insertion of elastic separator, happened within 24 hours.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of Hard Tissue Biology
Issue number2
Publication statusPublished - Jan 2007
Externally publishedYes


  • Mechanical stress
  • Osteoblasts
  • Osteoclasts
  • Periodontal ligament
  • Tissue reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • General Dentistry
  • Cell Biology


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