Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo

Yoshinosuke Hamada, Kanako Yuki, Masayuki Okazaki, Wataru Fujitani, Takuya Matsumoto, Michiyo Kobashi Hashida, Kentaro Harutsugu, Kiyoshi Nokihara, Michiharu Daito, Nariaki Matsuura, Junzo Takahashi

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Our previous study reported that an osteopontin-derived peptide SVVYGLR activates the adhesion, migration and tube formation abilities of endothelial cells in vitro. The present study investigated angiogenesis due to synthetic SVVYGLR and mutant peptides in vivo. Mutant peptides (n = 7) were synthesized by substituting alanine (A) for one of the 7 amino acids comprising SVVYGLR. In dorsal air sac assay, mouse dorsal skin 5 days after implantation of a chamber filled with SVVYGLR had approximately the same number of newly formed blood vessels to that filled with vascular endothelial growth factor (VEGF). The ability of angiogenesis due to SVVAGLR was significantly lower than that due to other 6 mutant peptides and SVVYGLR. This indicates that tyrosine (Y) plays an important role in angiogenesis due to SVVYGLR.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalDental materials journal
Issue number4
Publication statusPublished - Dec 2004
Externally publishedYes


  • Angiogenesis
  • Endothelial cells

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)


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