TY - JOUR
T1 - Oxepinamides
T2 - Novel liver X receptor agonists from aspergillus puniceus
AU - Lu, Xin Hua
AU - Shi, Qing Wen
AU - Zheng, Zhi Hui
AU - Ke, Ai Bing
AU - Zhang, Hua
AU - Huo, Chang Hong
AU - Ma, Ying
AU - Ren, Xiao
AU - Li, Ye Ying
AU - Lin, Jie
AU - Jiang, Qin
AU - Gu, Yu Cheng
AU - Kiyota, Hiromasa
PY - 2011/2
Y1 - 2011/2
N2 - Four novel oxepin-containing pyrimidines, namely oxepinamides D-G (1-4), were isolated from cultures of Aspergillus puniceus F02Z-1744. The structures of 1-4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single-crystal X-ray crystallographic analysis. All four compounds 1-4 showed transcriptional activation on Liver X Receptor α (LXRα) with EC 50 values of 10.6, 12.8, 13.6, and 12.1 μM, respectively. Oxepinamides D-G, which are four novel oxepin-containing pyrimidines, were isolated from cultures of Aspergillus puniceus F02Z-1744. All four compounds showed moderate transcriptional activation on LXRα (Liver X Receptor), whereas no effects were observed on FXRα, PPARα, PPARβ, PPARβ, RARα, RXRα, or ERα at concentrations of 30 μM.
AB - Four novel oxepin-containing pyrimidines, namely oxepinamides D-G (1-4), were isolated from cultures of Aspergillus puniceus F02Z-1744. The structures of 1-4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single-crystal X-ray crystallographic analysis. All four compounds 1-4 showed transcriptional activation on Liver X Receptor α (LXRα) with EC 50 values of 10.6, 12.8, 13.6, and 12.1 μM, respectively. Oxepinamides D-G, which are four novel oxepin-containing pyrimidines, were isolated from cultures of Aspergillus puniceus F02Z-1744. All four compounds showed moderate transcriptional activation on LXRα (Liver X Receptor), whereas no effects were observed on FXRα, PPARα, PPARβ, PPARβ, RARα, RXRα, or ERα at concentrations of 30 μM.
KW - Aspergillus puniceus
KW - Biological activity
KW - Heterocycles
KW - Natural products
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=79251621291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79251621291&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201000812
DO - 10.1002/ejoc.201000812
M3 - Article
AN - SCOPUS:79251621291
SN - 0075-4617
SP - 802
EP - 807
JO - Justus Liebigs Annalen der Chemie
JF - Justus Liebigs Annalen der Chemie
IS - 4
ER -