p53 and MDM2 expressionin oral squamous cell carcinoma

Tomohiro Matsumura; Yasuto Yoshihama; Takuji Kimura; Satoru Shintani; Rafael E. Alcalde

doi:10.1159/000227578

p53 and MDM2 expressionin oral squamous cell carcinoma

Tomohiro Matsumura, Yasuto Yoshihama, Takuji Kimura, Satoru Shintani, Rafael E. Alcalde

University Hospital

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31 % of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

Original language	English
Pages (from-to)	308-312
Number of pages	5
Journal	Oncology (Switzerland)
Volume	53
Issue number	4
DOIs	https://doi.org/10.1159/000227578
Publication status	Published - Jan 1 1996

Keywords

Gene
Immunohistochemistry
Leukoplakia
Oral squamous cell carcinoma
Protein
p53 MDM2

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000227578

Cite this

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title = "p53 and MDM2 expressionin oral squamous cell carcinoma",

abstract = "The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31 % of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.",

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author = "Tomohiro Matsumura and Yasuto Yoshihama and Takuji Kimura and Satoru Shintani and Alcalde, {Rafael E.}",

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AU - Matsumura, Tomohiro

AU - Yoshihama, Yasuto

AU - Kimura, Takuji

AU - Shintani, Satoru

AU - Alcalde, Rafael E.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31 % of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

AB - The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31 % of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

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KW - Immunohistochemistry

KW - Leukoplakia

KW - Oral squamous cell carcinoma

KW - Protein

KW - p53 MDM2

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p53 and MDM2 expressionin oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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