TY - JOUR
T1 - Paediatric lung transplantation
T2 - the impact of age on the survival
AU - Otani, Shinji
AU - Yamamoto, Haruchika
AU - Tanaka, Shin
AU - Tomioka, Yasuaki
AU - Matsubara, Kei
AU - Shimizu, Dai
AU - Shiotani, Toshio
AU - Suzawa, Ken
AU - Miyoshi, Kentaroh
AU - Yamamoto, Hiromasa
AU - Okazaki, Mikio
AU - Sugimoto, Seiichiro
AU - Yamane, Masaomi
AU - Toyooka, Shinichi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (20K09176) from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.
PY - 2022
Y1 - 2022
N2 - Objectives: We herein review the outcomes of paediatric lung transplantation (LTx) and analyse subgroups divided by age. Methods: We retrospectively reviewed 43 consecutive paediatric LTx recipients (< 18 years old: cadaveric LTx [n = 9], living-donor lobar LTx [n = 34]). We also analysed subgroups of patients 1–6 years old (n = 10) and 7–17 years old (n = 33). Results: The 1-, 5- and 10-year overall survival (OS) rates in paediatric recipients were 93%, 82% and 67%, respectively. The 1-, 5- and 10-year graft dysfunction (GD)-free survival rates in paediatric recipients were 85%, 59% and 31%, respectively. The 1- and 5-year OS in the 1- to 6-year-old vs. 7- to 17-year-old groups were 70% vs. 100% and 48% vs. 93%, respectively (p < 0.0001). The 1- and 5-year GD-free survival rates in the 1- to 6-year-old vs. 7- to 17-year-old groups were 60% vs. 93% and 24% vs. 69%, respectively (p = 0.024). The 1- to 6-year-old group showed higher rates of non-standard LTx (p = 0.0001), interstitial pneumonia (p = 0.004) and ventilator dependency (p = 0.007) than the 7- to 17-year-old group. Conclusion: Paediatric recipients under 7 years old seemed to have a higher risk of mortality and GD than those 7 years old and older.
AB - Objectives: We herein review the outcomes of paediatric lung transplantation (LTx) and analyse subgroups divided by age. Methods: We retrospectively reviewed 43 consecutive paediatric LTx recipients (< 18 years old: cadaveric LTx [n = 9], living-donor lobar LTx [n = 34]). We also analysed subgroups of patients 1–6 years old (n = 10) and 7–17 years old (n = 33). Results: The 1-, 5- and 10-year overall survival (OS) rates in paediatric recipients were 93%, 82% and 67%, respectively. The 1-, 5- and 10-year graft dysfunction (GD)-free survival rates in paediatric recipients were 85%, 59% and 31%, respectively. The 1- and 5-year OS in the 1- to 6-year-old vs. 7- to 17-year-old groups were 70% vs. 100% and 48% vs. 93%, respectively (p < 0.0001). The 1- and 5-year GD-free survival rates in the 1- to 6-year-old vs. 7- to 17-year-old groups were 60% vs. 93% and 24% vs. 69%, respectively (p = 0.024). The 1- to 6-year-old group showed higher rates of non-standard LTx (p = 0.0001), interstitial pneumonia (p = 0.004) and ventilator dependency (p = 0.007) than the 7- to 17-year-old group. Conclusion: Paediatric recipients under 7 years old seemed to have a higher risk of mortality and GD than those 7 years old and older.
KW - Lung
KW - Paediatric
KW - Transplantation
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U2 - 10.1007/s00595-022-02492-w
DO - 10.1007/s00595-022-02492-w
M3 - Article
C2 - 35357572
AN - SCOPUS:85127408101
SN - 0941-1291
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
ER -