Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Yasushi Nishihara; Daisuke Saito; Eiji Inoue; Yoshiaki Okada; Mikihiro Miyazaki; Yoshiaki Inoue; Kentaro Takagi

doi:10.1016/j.tetlet.2009.11.001

Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Yasushi Nishihara, Daisuke Saito, Eiji Inoue, Yoshiaki Okada, Mikihiro Miyazaki, Yoshiaki Inoue, Kentaro Takagi

Research Institute for Interdisciplinary Science

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Alkynylboronates can be employed as a practical and versatile precursor for a variety of π-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.

Original language	English
Pages (from-to)	306-308
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2009.11.001
Publication status	Published - Jan 13 2010

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.11.001

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title = "Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl",

abstract = "Alkynylboronates can be employed as a practical and versatile precursor for a variety of π-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.",

author = "Yasushi Nishihara and Daisuke Saito and Eiji Inoue and Yoshiaki Okada and Mikihiro Miyazaki and Yoshiaki Inoue and Kentaro Takagi",

note = "Funding Information: Y.N. acknowledges the financial assistance from National Science Council, ROC (NSC 098-2811-M-002-027 ) for stay in Taiwan.",

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T1 - Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

AU - Nishihara, Yasushi

AU - Saito, Daisuke

AU - Inoue, Eiji

AU - Okada, Yoshiaki

AU - Miyazaki, Mikihiro

AU - Inoue, Yoshiaki

AU - Takagi, Kentaro

N1 - Funding Information: Y.N. acknowledges the financial assistance from National Science Council, ROC (NSC 098-2811-M-002-027 ) for stay in Taiwan.

PY - 2010/1/13

Y1 - 2010/1/13

N2 - Alkynylboronates can be employed as a practical and versatile precursor for a variety of π-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.

AB - Alkynylboronates can be employed as a practical and versatile precursor for a variety of π-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.

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DO - 10.1016/j.tetlet.2009.11.001

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Abstract

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