Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration

Yutaka Akimoto; Hironari Kato; Kazuyuki Matsumoto; Ryo Harada; Shinsuke Oda; Soichiro Fushimi; Shou Mizukawa; Shuntaro Yabe; Daisuke Uchida; Hiroyuki Seki; Takeshi Tomoda; Naoki Yamamoto; Shigeru Horiguchi; Koichiro Tsutsumi; Takahito Yagi; Hiroyuki Okada

doi:10.2169/internalmedicine.55.6741

Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration

Yutaka Akimoto, Hironari Kato, Kazuyuki Matsumoto, Ryo Harada, Shinsuke Oda, Soichiro Fushimi, Shou Mizukawa, Shuntaro Yabe, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Takahito Yagi, Hiroyuki Okada

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Abstract

A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.

Original language	English
Pages (from-to)	2405-2411
Number of pages	7
Journal	Internal Medicine
Volume	55
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.55.6741
Publication status	Published - 2016

Keywords

EUS-FNA
Hepatoid carcinoma
Pancreatic tumor
Solid-pseudopapillary neoplasm
β-catenin

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.55.6741

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Akimoto, Y., Kato, H., Matsumoto, K., Harada, R., Oda, S., Fushimi, S., Mizukawa, S., Yabe, S., Uchida, D., Seki, H., Tomoda, T., Yamamoto, N., Horiguchi, S., Tsutsumi, K., Yagi, T., & Okada, H. (2016). Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration. Internal Medicine, 55(17), 2405-2411. https://doi.org/10.2169/internalmedicine.55.6741

Akimoto, Y, Kato, H , Matsumoto, K, Harada, R, Oda, S, Fushimi, S, Mizukawa, S, Yabe, S, Uchida, D, Seki, H, Tomoda, T, Yamamoto, N, Horiguchi, S , Tsutsumi, K , Yagi, T & Okada, H 2016, 'Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration', Internal Medicine, vol. 55, no. 17, pp. 2405-2411. https://doi.org/10.2169/internalmedicine.55.6741

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title = "Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration",

abstract = "A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.",

keywords = "EUS-FNA, Hepatoid carcinoma, Pancreatic tumor, Solid-pseudopapillary neoplasm, β-catenin",

author = "Yutaka Akimoto and Hironari Kato and Kazuyuki Matsumoto and Ryo Harada and Shinsuke Oda and Soichiro Fushimi and Shou Mizukawa and Shuntaro Yabe and Daisuke Uchida and Hiroyuki Seki and Takeshi Tomoda and Naoki Yamamoto and Shigeru Horiguchi and Koichiro Tsutsumi and Takahito Yagi and Hiroyuki Okada",

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doi = "10.2169/internalmedicine.55.6741",

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AU - Akimoto, Yutaka

AU - Kato, Hironari

AU - Matsumoto, Kazuyuki

AU - Harada, Ryo

AU - Oda, Shinsuke

AU - Fushimi, Soichiro

AU - Mizukawa, Shou

AU - Yabe, Shuntaro

AU - Uchida, Daisuke

AU - Seki, Hiroyuki

AU - Tomoda, Takeshi

AU - Yamamoto, Naoki

AU - Horiguchi, Shigeru

AU - Tsutsumi, Koichiro

AU - Yagi, Takahito

AU - Okada, Hiroyuki

PY - 2016

Y1 - 2016

N2 - A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.

AB - A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.

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KW - Hepatoid carcinoma

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KW - Solid-pseudopapillary neoplasm

KW - β-catenin

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Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration

Abstract

Keywords

ASJC Scopus subject areas

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