Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment

Masaru Kinomura; Noriaki Shimada; Mana Nishikawa; Kazuyoshi Omori; Tomoyasu Jo; Yasunori Ueda; Kenji Notohara; Riko Kitazawa; Sohei Kitazawa; Masaki Fukushima; Kenichiro Asano

doi:10.2169/internalmedicine.54.5085

Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment

Masaru Kinomura, Noriaki Shimada, Mana Nishikawa, Kazuyoshi Omori, Tomoyasu Jo, Yasunori Ueda, Kenji Notohara, Riko Kitazawa, Sohei Kitazawa, Masaki Fukushima, Kenichiro Asano

University Hospital

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.

Original language	English
Pages (from-to)	3029-3033
Number of pages	5
Journal	Internal Medicine
Volume	54
Issue number	23
DOIs	https://doi.org/10.2169/internalmedicine.54.5085
Publication status	Published - Dec 1 2015

Keywords

Cast nephropathy
Light chain deposition disease
PTHrP

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.54.5085

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title = "Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment",

abstract = "A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.",

keywords = "Cast nephropathy, Light chain deposition disease, PTHrP",

author = "Masaru Kinomura and Noriaki Shimada and Mana Nishikawa and Kazuyoshi Omori and Tomoyasu Jo and Yasunori Ueda and Kenji Notohara and Riko Kitazawa and Sohei Kitazawa and Masaki Fukushima and Kenichiro Asano",

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T1 - Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment

AU - Kinomura, Masaru

AU - Shimada, Noriaki

AU - Nishikawa, Mana

AU - Omori, Kazuyoshi

AU - Jo, Tomoyasu

AU - Ueda, Yasunori

AU - Notohara, Kenji

AU - Kitazawa, Riko

AU - Kitazawa, Sohei

AU - Fukushima, Masaki

AU - Asano, Kenichiro

PY - 2015/12/1

Y1 - 2015/12/1

N2 - A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.

AB - A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.

KW - Cast nephropathy

KW - Light chain deposition disease

KW - PTHrP

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Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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