Parenchymal changes of the liver in cholangiocarcinoma: CT evaluation

Yasuyuki Yamashita, Mutsumasa Takahashi, Susumu Kanazawa, Chusilp Charnsangavej, Sidney Wallace

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


We evaluated parenchymal changes of the liver in 92 patients (41 peripheral types and 51 hilar types) with cholangiocarcinomas studied by bolusenhanced computed tomography (CT). In 39% of patients with the peripheral type, a wedge-shaped increased enhancement of the liver was observed peripheral to the tumor on bolus-enhanced CT. Tumor was observed in all cases. In 58.8% of patients with the hilar type, a segmental or lobar increased degree of enhancement of the liver was observed, but the tumor was demonstrated in only 58.8%. Atrophy was accompanied by areas of increased enhancement in 80% of hilar type and 25% of peripheral type. Areas of increased degree of enhancement corresponded to a wedged-shaped perfusion defect on CT during arterial portography. On magnetic resonance imaging (MRI), those lesions showed hyperintensity on T2-weighted images. Most of these changes were considered to be due to reversible hepatic parenchymal ischemia secondary to portal vein invasion by the tumor.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalGastrointestinal Radiology
Issue number1
Publication statusPublished - Dec 1 1992
Externally publishedYes


  • Cholangiocarcinoma, liver
  • Liver atrophy
  • Liver infarction
  • Liver, MRI, CT
  • Portal vein

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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