Pathogenesis and therapeutic perspectives for amyotrophic lateral sclerosis (ALS)

Koji Abe

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


After gene mutations of SOD1 were found in familial amyotrophic lateral sclerosis (ALS) in 1993, many studies have elucidated pathogenesis of this progressive motor neuron disease. Among them, oxidative stress, impaired axonal transport, imbalance of survival & death signals, organellic stress (for mitochondria, endoplasmic reticulum and proteasome) are the most important with linking each other through energy failure within the motor neuron. New therapeutic approaches have also been tried, such as free radical scavenger edaravone, a continuous intra-thecal injection of neurotrophic factor IGF-1, and methylcobalamine as well as gene therapy with GDNF and regenerative therapy with stem cell activation and stem cell transplantation.

Original languageEnglish
Pages (from-to)790-794
Number of pages5
JournalClinical Neurology
Issue number11
Publication statusPublished - Nov 2007
Externally publishedYes


  • ALS
  • Gene therapy
  • Pathogenesis
  • Regenerative therapy
  • Therapeutic perspective

ASJC Scopus subject areas

  • Clinical Neurology


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