Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

Masahiro Sakata; Akinobu Takaki; Atsushi Oyama; Takuya Adachi; Nozomu Wada; Yasuto Takeuchi; Tetsuya Yasunaka; Hideki Onishi; Hidenori Shiraha; Hiroyuki Okada

doi:10.2739/kurumemedj.MS6723011

Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

Masahiro Sakata, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Onishi, Hidenori Shiraha, Hiroyuki Okada

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

Original language	English
Pages (from-to)	121-129
Number of pages	9
Journal	Kurume Medical Journal
Volume	67
Issue number	2-3
DOIs	https://doi.org/10.2739/kurumemedj.MS6723011
Publication status	Published - 2020

Keywords

anorexia nervosa
hepatic complication
refeeding syndrome
starvation induced liver injury

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2739/kurumemedj.MS6723011

Cite this

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abstract = "Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.",

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T1 - Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa

T2 - A Report of Two Cases and a Literature Review

AU - Sakata, Masahiro

AU - Takaki, Akinobu

AU - Oyama, Atsushi

AU - Adachi, Takuya

AU - Wada, Nozomu

AU - Takeuchi, Yasuto

AU - Yasunaka, Tetsuya

AU - Onishi, Hideki

AU - Shiraha, Hidenori

AU - Okada, Hiroyuki

PY - 2020

Y1 - 2020

N2 - Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

AB - Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

KW - anorexia nervosa

KW - hepatic complication

KW - refeeding syndrome

KW - starvation induced liver injury

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Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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