Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases

Zen Kobayashi, Ito Kawakami, Tetsuaki Arai, Osamu Yokota, Kuniaki Tsuchiya, Hiromi Kondo, Yoko Shimomura, Chie Haga, Naoya Aoki, Masato Hasegawa, Masato Hosokawa, Kenichi Oshima, Kazuhiro Niizato, Hideki Ishizu, Seishi Terada, Mitsumoto Onaya, Manabu Ikeda, Kiyomitsu Oyanagi, Imaharu Nakano, Shigeo MurayamaHaruhiko Akiyama, Hidehiro Mizusawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We investigated the pathological features of frontotemporal lobar degeneration (FTLD) with fused in sarcoma protein (FUS) accumulation (FTLD-FUS) in the Japanese population. Only one out of nine FTLD-FUS cases showed pathology that corresponds to atypical FTLD with ubiquitin-positive inclusions (aFTLD-U). Five were basophilic inclusion body disease (BIBD) and two were neuronal intermediate filament inclusion disease. The last case was unclassifiable and was associated with dystrophic neurites (DNs) as the predominant FUS pathology. The results of this study indicate an ethnic difference from western countries. In Japan, BIBD is the most common subtype of FTLD-FUS and aFTLD-U is rare, a finding which contrasts with aFTLD-U being the most common form in western countries. Immunohistochemical analyses of these FTLD-FUS cases reveal that FUS abnormally accumulated in neuronal cytoplasmic inclusions (NCIs) and DNs has an immunohistochemical profile distinct from that of normal, nuclear FUS. NCIs and DNs are more readily stained than the nuclei by antibodies to the middle portion of FUS. Antibodies to the carboxyl terminal portion, on the other hand, stain the nuclei more readily than NCIs and DNs. Such an immunohistochemical profile of NCIs and DNs was similar to that of cytoplasmic granular FUS staining which we previously reported to be associated with dendrites and synapses. Redistribution of FUS from the nucleus to the cytoplasm could be associated with the formation of abnormal FUS aggregates in FTLD-FUS.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalJournal of the neurological sciences
Issue number1-2
Publication statusPublished - Dec 15 2013


  • BIBD
  • Frontotemporal lobar degeneration
  • Fused in sarcoma
  • Immunohistochemistry
  • aFTLD-U

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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