Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Yuka Sogabe, Katsuya Miyatani, Rieko Goto, Gengo Ishii, Kohichi Ohshima, Yasuharu Sato

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalJapanese Journal of Ophthalmology
Issue number5
Publication statusPublished - Sept 2012


  • IgG4-related disease
  • Infraorbital nerve
  • Nerve tumor
  • Orbital tumor
  • Trigeminal nerve lesion

ASJC Scopus subject areas

  • Ophthalmology


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