PBSC collection from family donors in Japan: A prospective survey

Y. Kodera; K. Yamamoto; M. Harada; Y. Morishima; H. Dohy; S. Asano; Y. Ikeda; T. Nakahata; M. Imamura; K. Kawa; S. Kato; M. Tanimoto; Y. Kanda; R. Tanosaki; S. Shiobara; S. W. Kim; K. Nagafuji; M. Hino; K. Miyamura; R. Suzuki; N. Hamajima; M. Fukushima; A. Tamakoshi; J. Halter; N. Schmitz; D. Niederwieser; A. Gratwohl

doi:10.1038/bmt.2013.147

PBSC collection from family donors in Japan: A prospective survey

Y. Kodera, K. Yamamoto, M. Harada, Y. Morishima, H. Dohy, S. Asano, Y. Ikeda, T. Nakahata, M. Imamura, K. Kawa, S. Kato, M. Tanimoto, Y. Kanda, R. Tanosaki, S. Shiobara, S. W. Kim, K. Nagafuji, M. Hino, K. Miyamura, R. SuzukiN. Hamajima, M. Fukushima, A. Tamakoshi, J. Halter, N. Schmitz, D. Niederwieser, A. Gratwohl

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

Original language	English
Pages (from-to)	195-200
Number of pages	6
Journal	Bone Marrow Transplantation
Volume	49
Issue number	2
DOIs	https://doi.org/10.1038/bmt.2013.147
Publication status	Published - Feb 2014

Keywords

Acute adverse events
Family donors
Late health problems
PBSC harvest (PBSCH)
Predictive factors
Prospective study

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/bmt.2013.147

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Kodera, Y., Yamamoto, K., Harada, M., Morishima, Y., Dohy, H., Asano, S., Ikeda, Y., Nakahata, T., Imamura, M., Kawa, K., Kato, S., Tanimoto, M., Kanda, Y., Tanosaki, R., Shiobara, S., Kim, S. W., Nagafuji, K., Hino, M., Miyamura, K., ... Gratwohl, A. (2014). PBSC collection from family donors in Japan: A prospective survey. Bone Marrow Transplantation, 49(2), 195-200. https://doi.org/10.1038/bmt.2013.147

Kodera, Y, Yamamoto, K, Harada, M, Morishima, Y, Dohy, H, Asano, S, Ikeda, Y, Nakahata, T, Imamura, M, Kawa, K, Kato, S, Tanimoto, M, Kanda, Y, Tanosaki, R, Shiobara, S, Kim, SW, Nagafuji, K, Hino, M, Miyamura, K, Suzuki, R, Hamajima, N, Fukushima, M, Tamakoshi, A, Halter, J, Schmitz, N, Niederwieser, D & Gratwohl, A 2014, 'PBSC collection from family donors in Japan: A prospective survey', Bone Marrow Transplantation, vol. 49, no. 2, pp. 195-200. https://doi.org/10.1038/bmt.2013.147

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title = "PBSC collection from family donors in Japan: A prospective survey",

abstract = "Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.",

keywords = "Acute adverse events, Family donors, Late health problems, PBSC harvest (PBSCH), Predictive factors, Prospective study",

author = "Y. Kodera and K. Yamamoto and M. Harada and Y. Morishima and H. Dohy and S. Asano and Y. Ikeda and T. Nakahata and M. Imamura and K. Kawa and S. Kato and M. Tanimoto and Y. Kanda and R. Tanosaki and S. Shiobara and Kim, {S. W.} and K. Nagafuji and M. Hino and K. Miyamura and R. Suzuki and N. Hamajima and M. Fukushima and A. Tamakoshi and J. Halter and N. Schmitz and D. Niederwieser and A. Gratwohl",

note = "Funding Information: We thank R Kodera, K Kawai, T Shimizu and Y Yamada (EPS Co.) for their generous assistance in the course of the survey. The study was partially supported by Health and Labor Sciences Research Grants, Research on Tissue Engineering, Ministry of Health, Labor and Welfare, Japan. JH and AG were in part supported by the Swiss National Foundation grant NRP 63.",

year = "2014",

month = feb,

doi = "10.1038/bmt.2013.147",

language = "English",

volume = "49",

pages = "195--200",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - PBSC collection from family donors in Japan

T2 - A prospective survey

AU - Kodera, Y.

AU - Yamamoto, K.

AU - Harada, M.

AU - Morishima, Y.

AU - Dohy, H.

AU - Asano, S.

AU - Ikeda, Y.

AU - Nakahata, T.

AU - Imamura, M.

AU - Kawa, K.

AU - Kato, S.

AU - Tanimoto, M.

AU - Kanda, Y.

AU - Tanosaki, R.

AU - Shiobara, S.

AU - Kim, S. W.

AU - Nagafuji, K.

AU - Hino, M.

AU - Miyamura, K.

AU - Suzuki, R.

AU - Hamajima, N.

AU - Fukushima, M.

AU - Tamakoshi, A.

AU - Halter, J.

AU - Schmitz, N.

AU - Niederwieser, D.

AU - Gratwohl, A.

N1 - Funding Information: We thank R Kodera, K Kawai, T Shimizu and Y Yamada (EPS Co.) for their generous assistance in the course of the survey. The study was partially supported by Health and Labor Sciences Research Grants, Research on Tissue Engineering, Ministry of Health, Labor and Welfare, Japan. JH and AG were in part supported by the Swiss National Foundation grant NRP 63.

PY - 2014/2

Y1 - 2014/2

N2 - Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

AB - Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

KW - Acute adverse events

KW - Family donors

KW - Late health problems

KW - PBSC harvest (PBSCH)

KW - Predictive factors

KW - Prospective study

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PBSC collection from family donors in Japan: A prospective survey

Abstract

Keywords

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