Pedigree analysis of factor XI deficiency in Japanese black cattle

Yasunori Ohba, Masaki Takasu, Naohito Nishii, Eri Takeda, Sadatoshi Maeda, Tetsuo Kunieda, Hitoshi Kitagawa

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    12 Citations (Scopus)

    Abstract

    Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle.

    Original languageEnglish
    Pages (from-to)297-299
    Number of pages3
    JournalJournal of Veterinary Medical Science
    Volume70
    Issue number3
    DOIs
    Publication statusPublished - Mar 2008

    Keywords

    • Factor XI deficiency
    • Gene frequency
    • Japanese black cattle

    ASJC Scopus subject areas

    • General Veterinary

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