Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC13-aqueous NaCl-H2SO4-(Pt electrodes) system and subsequent ring closure with NH3 in DMF.
|Number of pages||2|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry