Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ3-cephems

Sigeru Torii; Hideo Tanaka; Norio Saitoh; Takashi Siroi; Michio Sasaoka; Junzo Nokami

doi:10.1016/S0040-4039(00)87295-0

Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ³-cephems

Sigeru Torii, Hideo Tanaka, Norio Saitoh, Takashi Siroi, Michio Sasaoka, Junzo Nokami

Faculty of Engineering

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Synthesis of 3-chloromethyl-Δ³-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC1₃-aqueous NaCl-H₂SO₄-(Pt electrodes) system and subsequent ring closure with NH₃ in DMF.

Original language	English
Pages (from-to)	2187-2188
Number of pages	2
Journal	Tetrahedron Letters
Volume	23
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)87295-0
Publication status	Published - 1982

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ3-cephems",

abstract = "Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC13-aqueous NaCl-H2SO4-(Pt electrodes) system and subsequent ring closure with NH3 in DMF.",

author = "Sigeru Torii and Hideo Tanaka and Norio Saitoh and Takashi Siroi and Michio Sasaoka and Junzo Nokami",

year = "1982",

doi = "10.1016/S0040-4039(00)87295-0",

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T1 - Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ3-cephems

AU - Torii, Sigeru

AU - Tanaka, Hideo

AU - Saitoh, Norio

AU - Siroi, Takashi

AU - Sasaoka, Michio

AU - Nokami, Junzo

PY - 1982

Y1 - 1982

N2 - Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC13-aqueous NaCl-H2SO4-(Pt electrodes) system and subsequent ring closure with NH3 in DMF.

AB - Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC13-aqueous NaCl-H2SO4-(Pt electrodes) system and subsequent ring closure with NH3 in DMF.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ³-cephems

Abstract

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