Direct transformation of thiazoline-azetidinones 2, derived from penicillin G and V, into 3′-thio-substituted cephalosporins 4 has been performed by ring opening of the thiazoline moiety with sulfenyl chlorides followed by ring closure with NH3 in dimethylformamide and simultaneous displacement of the allylic chlorine atom with the leaving thiolates.
|Number of pages||4|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry