Perioperative change of ionized magnesium concentration - Effect of blood transfusion

Osamu Nagano, Susumu Iwadoh, Yumi Sanagawa, Yoshimasa Takeda, Masanao Yokoyama, Hiroshi Katayama, Masahisa Hirakawa

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In order to evaluate the effect of intra-operative blood transfusion on post-operative decrease of ionized Mg (Mg 2+), we performed following studies. 1) We measured ionized Mg (Mg 2+), total Mg, ionized Ca (Ca 2+), total Ca and citrate before and after operation in 70 patients. 2) We evaluated the effect of citrate on Mg 2+ and Ca 2+ in vitro. 3) We also measured these values during blood transfusion in 8 patients. There was no significant difference between post-operative Mg 2+ of 45 patients without blood transfusion (0.49±0.07 mmol · l -1, % decrease from pre-operative value was 13.4± 9.2%; mean±SD), and that of 25 patients with blood transfusion (0.48±0.09mmol · l -1, 17.9±10.2%). Mean value of post-operative citrate concentration of patients with blood transfusion was 0.15±0.11 mmol · l -1, and this value decreased Mg 2+ about 2% in in vitro study. During blood transfusion, Mg 2+ (0.41±0.05 mmol · l -1) and ionized % (54.5±8.3%) decreased significantly just like Ca 2+ with elevated citrate concentration (0.95±0.59 mmol · l -1). In conclusion, intra-operative blood transfusion had minor effect on the post-operative decrease of Mg 2+, and the major cause was thought to be the dilution of extracellular fluid by Mg-free fluid administered during operation.

Original languageEnglish
Pages (from-to)632-633
Number of pages2
JournalJapanese Journal of Anesthesiology
Issue number6
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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