TY - JOUR
T1 - Peripheral T/natural killer-cell lymphoma involving the female genital tract
T2 - a clinicopathologic study of 5 cases
AU - Nakamura, Shigeo
AU - Kato, Miyuki
AU - Ichimura, Koichi
AU - Yatabe, Yasushi
AU - Kagami, Yoshitoyo
AU - Suzuki, Ritsuro
AU - Taji, Hirohumi
AU - Kondo, Eisei
AU - Asakura, Shoji
AU - Kojima, Masaru
AU - Murakami, Sakae
AU - Yamao, Kumi
AU - Tsuzuki, Toyonori
AU - Adachi, Koichi
AU - Miwa, Atsuo
AU - Yoshida, Takashi
N1 - Funding Information:
The authors thank H. Ishida for technical assistance. This work was supported in part by a grant-in-aid from the Ministry of Education, Science and Culture of Japan, and a grant-in-aid from the Ministry of Health and Welfare of Japan.
PY - 2001/1
Y1 - 2001/1
N2 - Malignant lymphoma of the female genital tract (FGT) is rare. In this study, 5 peripheral T/natural killer (NK)-cell lymphomas (PTCLs) involving the FGT are reported. They include 2 from the uterus and 1 each from ovary, uterus and ovary, and vagina, and were detected between 1996 and 2000. One of the 2 ovarian tumors was bilateral. In all cases, the FGT was the initial site of clinical presentation of disease. Age at presentation ranged from 21 to 52 years (median, 36 years). One case was stage I disease, 2 were stage II, and 2 were stage IV. All 5 tumors were positive for CD3epsilon, and 3 harbored the Epstein-Barr virus, although the detailed immunophenotypic profiles varied. Three were diagnosed as nasal type T/NK-cell lymphoma, 1 as anaplastic large-cell lymphoma (anaplastic lymphoma kinase [ALK]-positive), and 1 as unspecified PTCL of cytotoxic phenotype, according to the forthcoming World Health Organization classification. Four of 5 patients received laparotomy and chemotherapy. Four patients (in stages II and IV) died of disease within 16 months of the initial diagnosis, whereas only 1 patient (in stage I) is alive without disease at 39 months of follow-up. Our experience in this series provided clinically relevant information on diagnosis, treatment, and outcome for extremely rare tumors of the FGT.
AB - Malignant lymphoma of the female genital tract (FGT) is rare. In this study, 5 peripheral T/natural killer (NK)-cell lymphomas (PTCLs) involving the FGT are reported. They include 2 from the uterus and 1 each from ovary, uterus and ovary, and vagina, and were detected between 1996 and 2000. One of the 2 ovarian tumors was bilateral. In all cases, the FGT was the initial site of clinical presentation of disease. Age at presentation ranged from 21 to 52 years (median, 36 years). One case was stage I disease, 2 were stage II, and 2 were stage IV. All 5 tumors were positive for CD3epsilon, and 3 harbored the Epstein-Barr virus, although the detailed immunophenotypic profiles varied. Three were diagnosed as nasal type T/NK-cell lymphoma, 1 as anaplastic large-cell lymphoma (anaplastic lymphoma kinase [ALK]-positive), and 1 as unspecified PTCL of cytotoxic phenotype, according to the forthcoming World Health Organization classification. Four of 5 patients received laparotomy and chemotherapy. Four patients (in stages II and IV) died of disease within 16 months of the initial diagnosis, whereas only 1 patient (in stage I) is alive without disease at 39 months of follow-up. Our experience in this series provided clinically relevant information on diagnosis, treatment, and outcome for extremely rare tumors of the FGT.
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U2 - 10.1007/BF02981911
DO - 10.1007/BF02981911
M3 - Article
C2 - 11372745
AN - SCOPUS:0035235269
SN - 0925-5710
VL - 73
SP - 108
EP - 114
JO - International journal of hematology
JF - International journal of hematology
IS - 1
ER -