Persistent hypercholesterolaemia in frequently relapsing steroid- responsive nephrotic syndrome

H. Tsukahara, S. Haruki, M. Hiraoka, C. Hori, M. Sudo

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective: To investigate long-term changes of serum cholesterol levels in children with frequently relapsing steroid-responsive nephrotic syndrome (NS). Methodology: Serum cholesterol values just before and during or immediately after 'relapse' were reviewed and the incidence of hypercholesterolaemia (≤200 mg/dL) was determined in eight patients (M:F, 6:2). Results: The patients with frequently relapsing NS usually showed hypercholesterolaemia (mean incidence, 81%) just before 'relapse' during clinical remission, as well as in relapse (mean incidence, 96%). A high incidence of steroid therapy was also found in each case (mean, 89%) just before relapse. Conclusions: Our results demonstrate that children with frequently relapsing NS have prolonged periods of hypercholesterolaemia, even during clinical remission. It is suggested that serum lipid profiles be monitored carefully in such patients.

Original languageEnglish
Pages (from-to)253-255
Number of pages3
JournalJournal of Paediatrics and Child Health
Issue number3
Publication statusPublished - 1997
Externally publishedYes


  • Hypercholesterolaemia
  • Nephrotic syndrome
  • Steroid therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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