TY - JOUR
T1 - Perticipation of IL-18 in human cholestatic cirrhosis and acute rejection - Analysis in living donor liver transplantation
AU - Yagi, Takahito
AU - Iwagaki, Hiromi
AU - Urushihara, Naoto
AU - Oishi, Masahiro
AU - Kobashi, Kenta
AU - Kohka, Hideo
AU - Sadamori, Hiroshi
AU - Inagaki, Masaru
AU - Takakura, Norihisa
AU - Higashi, Toshihiro
AU - Tsuji, Takao
AU - Yoshino, Tadashi
AU - Tanimoto, Tadao
AU - Kurimoto, Masashi
AU - Tanaka, Noriaki
PY - 1999/12
Y1 - 1999/12
N2 - We herein report the relationship between IL-18 and pathogenesis in patients who have cholestatic cirrhosis and acute rejection after living donor liver transplantation. Twenty-one healthy volunteers (control) and patients with obstructive jaundice (OBJ, n = 4), endostage PBC (PBC, n = 7), biliary atresia after failed Kasai's operation (BATx, n = 4) and biliary atresia after successful Kasai's operation (BANTx, n = 4) were examined. Altough serum IL-18 levels were closely correlated with total bilirubin levels in these patients, there were significant differences in sIL-18 levels between OBJ and PBC plus BA group. In all groups, hyper IL-18nemia was not accompanied by IFN-γ production. Since 6 patients (2 PBC and 4 BATx) underwent living donor liver transplantation. (LDLT) , post-transplant cytokine producing profiles including IFN-γ , IL-6, -10, -12, -18 were determined. After LDLT, IFN-γ levels in recipients'serum were increased and IFN-γ producing property of recipients was improved. Furthermore, sIL-18 levels were closely related with rejectional episodes after LDLT. IL-18 may be a key substance which regulates development of human cholestatic liver diseases and rejection after liver transplantation.
AB - We herein report the relationship between IL-18 and pathogenesis in patients who have cholestatic cirrhosis and acute rejection after living donor liver transplantation. Twenty-one healthy volunteers (control) and patients with obstructive jaundice (OBJ, n = 4), endostage PBC (PBC, n = 7), biliary atresia after failed Kasai's operation (BATx, n = 4) and biliary atresia after successful Kasai's operation (BANTx, n = 4) were examined. Altough serum IL-18 levels were closely correlated with total bilirubin levels in these patients, there were significant differences in sIL-18 levels between OBJ and PBC plus BA group. In all groups, hyper IL-18nemia was not accompanied by IFN-γ production. Since 6 patients (2 PBC and 4 BATx) underwent living donor liver transplantation. (LDLT) , post-transplant cytokine producing profiles including IFN-γ , IL-6, -10, -12, -18 were determined. After LDLT, IFN-γ levels in recipients'serum were increased and IFN-γ producing property of recipients was improved. Furthermore, sIL-18 levels were closely related with rejectional episodes after LDLT. IL-18 may be a key substance which regulates development of human cholestatic liver diseases and rejection after liver transplantation.
KW - Acute rejection
KW - Cholestatic cirrhosis
KW - IL-18
UR - http://www.scopus.com/inward/record.url?scp=24144473087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24144473087&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:24144473087
SN - 0386-3603
VL - 27
SP - 85
EP - 92
JO - Japanese Pharmacology and Therapeutics
JF - Japanese Pharmacology and Therapeutics
IS - SUPPL. 7
ER -
