TY - JOUR
T1 - Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane
AU - Narimatsu, S.
AU - Shimozaki, K.
AU - Sugiyama, T.
AU - Yagi, I.
AU - Watanabe, K.
AU - Yamamoto, I.
AU - Yoshimura, H.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - A nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9- trimethyloxazolo-[5,4-a]-6H-dibenzopyrane (CBN-Ox), was synthesized from cannabinol (CBN) and its pharmacological activities in mice were compared with those of CBN using 3 indices of catalepsy, barbiturate synergism, and locomotor activity by intracerebroventricular injection. Pharmacological potencies of CBN-Ox were higher in cataleptogenic effect, but lower in barbiturate synergism and suppression of locomotor activity than those of CBN, suggesting that CBN-Ox may have some psychotropic activity in mice.
AB - A nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9- trimethyloxazolo-[5,4-a]-6H-dibenzopyrane (CBN-Ox), was synthesized from cannabinol (CBN) and its pharmacological activities in mice were compared with those of CBN using 3 indices of catalepsy, barbiturate synergism, and locomotor activity by intracerebroventricular injection. Pharmacological potencies of CBN-Ox were higher in cataleptogenic effect, but lower in barbiturate synergism and suppression of locomotor activity than those of CBN, suggesting that CBN-Ox may have some psychotropic activity in mice.
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M3 - Article
AN - SCOPUS:0026725994
SN - 0193-0818
VL - 13
SP - 247
EP - 255
JO - Research Communications in Substances of Abuse
JF - Research Communications in Substances of Abuse
IS - 3
ER -