@article{7b24067bea9540a083cb58cef6f2f475,
title = "Phase I/IIa study of low dose subcutaneous interleukin-2 (IL-2) for treatment of refractory chronic graft versus host disease",
abstract = "Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT.",
keywords = "Allogeneic HSCT, Chronic GVHD, IL-2, Steroid refractory",
author = "Takeru Asano and Matsuoka, {Ken Ichi} and Satoshi Iyama and Kazuteru Ohashi and Yoshihiro Inamoto and Chikako Ohwada and Makoto Murata and Atsushi Satake and Chikamasa Yoshida and Koichi Nakase and Yasuo Mori and Mitsune Tanimoto",
note = "Funding Information: Acknowledgments. The authors wish to acknowledge and thank the coordinators and all other investigators who contributed to this study. This protocol writing has been conducted with the support from Center for Innovative Clinical Medicine, ?kayama ?niversity Hospital. This work was supported by MHLW ?A???HI Grant ?umber 201433012A. Funding Information: The authors wish to acknowledge and thank the coordinators and all other investigators who contributed to this study. This protocol writing has been conducted with the support from Center for Innovative Clinical Medicine, Okayama University Hospital. This work was supported by MHLW KAKENHI Grant Number 201433012A Publisher Copyright: {\textcopyright} 2016 by Okayama University Medical School.",
year = "2016",
language = "English",
volume = "70",
pages = "429--433",
journal = "Acta medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "5",
}