Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase

Tsutomu Hatano; Taeko Yasuhara; Toshiyuki Fukuda; Tadataka Noro; Takuo Okuda

doi:10.1248/cpb.37.3005

Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase

Tsutomu Hatano, Taeko Yasuhara, Toshiyuki Fukuda, Tadataka Noro, Takuo Okuda

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data, Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3—5.6 x 10⁵M.

Original language	English
Pages (from-to)	3005-3009
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	37
Issue number	11
DOIs	https://doi.org/10.1248/cpb.37.3005
Publication status	Published - 1989

Keywords

Glycyrrhiza
centrifugal partition chromatography
droplet countercurrent chromatography
glisoflavone
kaempferol 3-O-methyl ether
licoarylcoumarin
licocoumarone
licopyranocoumarin
licorice
xanthine oxidase

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.37.3005

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Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase. / Hatano, Tsutomu; Yasuhara, Taeko; Fukuda, Toshiyuki et al.
In: Chemical and Pharmaceutical Bulletin, Vol. 37, No. 11, 1989, p. 3005-3009.

Research output: Contribution to journal › Article › peer-review

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abstract = "An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data, Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3—5.6 x 105M.",

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author = "Tsutomu Hatano and Taeko Yasuhara and Toshiyuki Fukuda and Tadataka Noro and Takuo Okuda",

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AU - Yasuhara, Taeko

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AU - Noro, Tadataka

AU - Okuda, Takuo

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N2 - An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data, Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3—5.6 x 105M.

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KW - licopyranocoumarin

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KW - xanthine oxidase

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Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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