Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Tomomi Noguchi; Hiroko Sano; Rumiko Shimazawa; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1016/j.bmcl.2004.06.026

Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Tomomi Noguchi, Hiroko Sano, Rumiko Shimazawa, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.

Original language	English
Pages (from-to)	4141-4145
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2004.06.026
Publication status	Published - Aug 16 2004

Keywords

NOS inhibitors
Structural development
Thalidomide

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.06.026

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title = "Phenylhomophthalimide-type NOS inhibitors derived from thalidomide",

abstract = "Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.",

keywords = "NOS inhibitors, Structural development, Thalidomide",

author = "Tomomi Noguchi and Hiroko Sano and Rumiko Shimazawa and Aya Tanatani and Hiroyuki Miyachi and Yuichi Hashimoto",

note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology, Japan, and Japan Society for the Promotion of Science.",

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T1 - Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

AU - Noguchi, Tomomi

AU - Sano, Hiroko

AU - Shimazawa, Rumiko

AU - Tanatani, Aya

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

N1 - Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology, Japan, and Japan Society for the Promotion of Science.

PY - 2004/8/16

Y1 - 2004/8/16

N2 - Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.

AB - Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.

KW - NOS inhibitors

KW - Structural development

KW - Thalidomide

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JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Abstract

Keywords

ASJC Scopus subject areas

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