TY - GEN
T1 - Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth
AU - Yoshida, Yasuhiro
AU - Okihara, Takumi
AU - Nakamura, Mariko
AU - Matsumoto, Takuya
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - A biodegradable material that bonds to hard tissues such as bones and teeth is urgently needed for medical and dental applications. However, such materials are not available in today's clinical practice of orthopedics and dentistry. Therefore, we synthesized biodegradable phosphorylated pullulan to develop a biomaterial that combines primary properties such as high biocompatibility, good bonding potential to hard tissue, high strength, biodegradability, and osteoconductivity. The pharmacopoeial polysaccharide pullulan was chemically functionalized with dihydrogen phosphate groups. Phosphorylated pullulan was formed network by adding calcium ion, making the composite less soluble in water. Adhesive force measurement revealed that adhesiveness of the pastes before setting can be controlled through optimization of additives. In addition, histological evaluation revealed that phosphorylated pullulan-based composite possesses high biocompatibility. These results indicate that phosphorylated pullulan can be used as a key material for regeneration and reconstruction of bone and tooth.
AB - A biodegradable material that bonds to hard tissues such as bones and teeth is urgently needed for medical and dental applications. However, such materials are not available in today's clinical practice of orthopedics and dentistry. Therefore, we synthesized biodegradable phosphorylated pullulan to develop a biomaterial that combines primary properties such as high biocompatibility, good bonding potential to hard tissue, high strength, biodegradability, and osteoconductivity. The pharmacopoeial polysaccharide pullulan was chemically functionalized with dihydrogen phosphate groups. Phosphorylated pullulan was formed network by adding calcium ion, making the composite less soluble in water. Adhesive force measurement revealed that adhesiveness of the pastes before setting can be controlled through optimization of additives. In addition, histological evaluation revealed that phosphorylated pullulan-based composite possesses high biocompatibility. These results indicate that phosphorylated pullulan can be used as a key material for regeneration and reconstruction of bone and tooth.
KW - Bioadhesive
KW - Bone
KW - Phosphorylated pullulan
KW - Reconstruction
KW - Regeneration
KW - Tooth
UR - http://www.scopus.com/inward/record.url?scp=84871308711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871308711&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.529-530.516
DO - 10.4028/www.scientific.net/KEM.529-530.516
M3 - Conference contribution
AN - SCOPUS:84871308711
SN - 9783037855171
T3 - Key Engineering Materials
SP - 516
EP - 521
BT - Bioceramics 24
PB - Trans Tech Publications Ltd
T2 - 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Y2 - 21 October 2012 through 24 October 2012
ER -