Pilot analysis of asbestos-induced difuse pleural thickening with respiratory compromise

Daisuke Nojima, Nobukazu Fujimoto, Katsuya Kato, Yasuko Fuchimoto, Katsuyuki Kiura, Takumi Kishimoto, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


AbstrcatWe investigated the clinical features of asbestos-induced diffuse pleural thickening (DPT) with severe respiratory compromise. We conducted a retrospective study of consecutive subjects with asbestosinduced DPT. Medical data such as initial symptoms, radiological findings, respiratory function test results, and clinical course were collected and analyzed. There were 24 patients between 2003 and 2012. All were men, and the median age at the development of DPT was 74 years. The top occupational category associated with asbestos exposure was dockyard workers. The median duration of asbestos exposure was 35.0 years, and the median latency from first exposure to the onset of DPT was 49.0 years. There were no significant differences in respiratory function test results between the higher and lower Brinkman index groups or between unilateral and bilateral DPT. Thirteen patients had a history of benign asbestos pleural effusion (BAPE), and the median duration from pleural fluid accumulation to DPT with severe respiratory compromise was 28.4 months. DPT with severe respiratory compromise can develop after a long latency following occupational asbestos exposure and a history of BAPE.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2015


  • Asbestos
  • Costophrenic angle
  • MRC dyspnea scale
  • Pleural thickening
  • Respiratory function test

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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