TY - JOUR
T1 - Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry
AU - Yoshioka, Hidefumi
AU - Meno, Chikara
AU - Koshiba, Kazuko
AU - Sugihara, Minoru
AU - Itoh, Hiroyuki
AU - Ishimaru, Yoshiyasu
AU - Inoue, Takashi
AU - Ohuchi, Hideyo
AU - Semina, Elena V.
AU - Murray, Jeffrey C.
AU - Hamada, Hiroshi
AU - Noji, Sumihare
N1 - Funding Information:
We thank C. Tabin for nodal, J. Cook for cSnR, and R. T. Yu for critical reading of the manuscript. This work was partly supported by grants from the Ministry of Education, Science and Culture of Japan to H. H. and S. N., from “Research for the Future Program” to S. N., by Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation to H. H., and by a Special Coordinate Funds for Promoting Science and Technology from the Science and Technology Agency of Japan to S. N.
PY - 1998/8/7
Y1 - 1998/8/7
N2 - Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid- type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.
AB - Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid- type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.
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U2 - 10.1016/S0092-8674(00)81473-7
DO - 10.1016/S0092-8674(00)81473-7
M3 - Article
C2 - 9708732
AN - SCOPUS:0032493866
SN - 0092-8674
VL - 94
SP - 299
EP - 305
JO - Cell
JF - Cell
IS - 3
ER -