Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

Sanae Ikehara; Hajime Sakakita; Kenji Ishikawa; Yoshihiro Akimoto; Takashi Yamaguchi; Masahiro Yamagishi; Jaeho Kim; Masashi Ueda; Jun Ichiro Ikeda; Hayao Nakanishi; Nobuyuki Shimizu; Masaru Hori; Yuzuru Ikehara

doi:10.1002/ppap.201500132

Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

Sanae Ikehara, Hajime Sakakita, Kenji Ishikawa, Yoshihiro Akimoto, Takashi Yamaguchi, Masahiro Yamagishi, Jaeho Kim, Masashi Ueda, Jun Ichiro Ikeda, Hayao Nakanishi, Nobuyuki Shimizu, Masaru Hori, Yuzuru Ikehara

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.

Original language	English
Pages (from-to)	1348-1353
Number of pages	6
Journal	Plasma Processes and Polymers
Volume	12
Issue number	12
DOIs	https://doi.org/10.1002/ppap.201500132
Publication status	Published - Dec 1 2015

Keywords

coagulation
hemostasis
nonthermal plasma
protein aggregation

ASJC Scopus subject areas

Condensed Matter Physics
Polymers and Plastics

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10.1002/ppap.201500132

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title = "Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors",

abstract = "The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.",

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T1 - Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

AU - Ikehara, Sanae

AU - Sakakita, Hajime

AU - Ishikawa, Kenji

AU - Akimoto, Yoshihiro

AU - Yamaguchi, Takashi

AU - Yamagishi, Masahiro

AU - Kim, Jaeho

AU - Ueda, Masashi

AU - Ikeda, Jun Ichiro

AU - Nakanishi, Hayao

AU - Shimizu, Nobuyuki

AU - Hori, Masaru

AU - Ikehara, Yuzuru

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.

AB - The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.

KW - coagulation

KW - hemostasis

KW - nonthermal plasma

KW - protein aggregation

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Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

Abstract

Keywords

ASJC Scopus subject areas

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