PNA arrays for miRNA detection

Tamaki Endoh; Mizuki Kitamatsu; Masahiko Sisido; Takashi Ohtsuki

doi:10.1246/cl.2009.438

PNA arrays for miRNA detection

Tamaki Endoh, Mizuki Kitamatsu, Masahiko Sisido, Takashi Ohtsuki

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6 Citations (Scopus)

Abstract

The profiling of microRNAs (miRNAs) using microarray technology has been used in many recent biological and medical studies. In this study, arrays of peptide nucleic acids (PNAs) were prepared and their miRNA capture abilities were evaluated. We found that the sensitivity of 10-mer PNA probes in targeting miRNAs was much higher than that of the corresponding DNA probes and also of longer (20-mer) DNA probes.

Original language	English
Pages (from-to)	438-439
Number of pages	2
Journal	Chemistry Letters
Volume	38
Issue number	5
DOIs	https://doi.org/10.1246/cl.2009.438
Publication status	Published - 2009

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2009.438

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title = "PNA arrays for miRNA detection",

abstract = "The profiling of microRNAs (miRNAs) using microarray technology has been used in many recent biological and medical studies. In this study, arrays of peptide nucleic acids (PNAs) were prepared and their miRNA capture abilities were evaluated. We found that the sensitivity of 10-mer PNA probes in targeting miRNAs was much higher than that of the corresponding DNA probes and also of longer (20-mer) DNA probes.",

author = "Tamaki Endoh and Mizuki Kitamatsu and Masahiko Sisido and Takashi Ohtsuki",

year = "2009",

doi = "10.1246/cl.2009.438",

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journal = "Chemistry Letters",

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T1 - PNA arrays for miRNA detection

AU - Endoh, Tamaki

AU - Kitamatsu, Mizuki

AU - Sisido, Masahiko

AU - Ohtsuki, Takashi

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Y1 - 2009

N2 - The profiling of microRNAs (miRNAs) using microarray technology has been used in many recent biological and medical studies. In this study, arrays of peptide nucleic acids (PNAs) were prepared and their miRNA capture abilities were evaluated. We found that the sensitivity of 10-mer PNA probes in targeting miRNAs was much higher than that of the corresponding DNA probes and also of longer (20-mer) DNA probes.

AB - The profiling of microRNAs (miRNAs) using microarray technology has been used in many recent biological and medical studies. In this study, arrays of peptide nucleic acids (PNAs) were prepared and their miRNA capture abilities were evaluated. We found that the sensitivity of 10-mer PNA probes in targeting miRNAs was much higher than that of the corresponding DNA probes and also of longer (20-mer) DNA probes.

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DO - 10.1246/cl.2009.438

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PNA arrays for miRNA detection

Abstract

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