Pneumonitis induced by rifampicin

N. Kunichika; N. Miyahara; K. Kotani; H. Takeyama; M. Harada; Mitsune Tanimoto

doi:10.1136/thorax.57.11.1000

Pneumonitis induced by rifampicin

N. Kunichika, N. Miyahara, K. Kotani, H. Takeyama, M. Harada, Mitsune Tanimoto

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

An 81 year old man was admitted to hospital with pulmonary Mycobacterium tuberculosis infection and was treated with rifampicin (RFP), isoniazid (INH), and ethambutol (EB). On day 9 he developed fever and dyspnoea. Chest radiographs showed new infiltration shadows in the right lung. Bronchoalveolar lavage (BAL) was performed and increased numbers of lymphocytes were recovered. Drug induced pneumonitis was suspected so the antituberculous regimen was discontinued and methylprednisolone was administered. The symptoms and infiltration shadows improved. INH and EB were reintroduced without any recurrence of the abnormal shadows. T cell subsets in the BAL fluid and a positive lymphocyte stimulation test for RFP suggest that RFP induced pneumonitis may be related to a complex immunological response.

Original language	English
Pages (from-to)	1000-1001
Number of pages	2
Journal	Thorax
Volume	57
Issue number	11
DOIs	https://doi.org/10.1136/thorax.57.11.1000
Publication status	Published - Nov 1 2002

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thorax.57.11.1000

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T1 - Pneumonitis induced by rifampicin

AU - Kunichika, N.

AU - Miyahara, N.

AU - Kotani, K.

AU - Takeyama, H.

AU - Harada, M.

AU - Tanimoto, Mitsune

PY - 2002/11/1

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AB - An 81 year old man was admitted to hospital with pulmonary Mycobacterium tuberculosis infection and was treated with rifampicin (RFP), isoniazid (INH), and ethambutol (EB). On day 9 he developed fever and dyspnoea. Chest radiographs showed new infiltration shadows in the right lung. Bronchoalveolar lavage (BAL) was performed and increased numbers of lymphocytes were recovered. Drug induced pneumonitis was suspected so the antituberculous regimen was discontinued and methylprednisolone was administered. The symptoms and infiltration shadows improved. INH and EB were reintroduced without any recurrence of the abnormal shadows. T cell subsets in the BAL fluid and a positive lymphocyte stimulation test for RFP suggest that RFP induced pneumonitis may be related to a complex immunological response.

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Pneumonitis induced by rifampicin

Abstract

ASJC Scopus subject areas

UN SDGs

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