TY - JOUR
T1 - Polycyclic n-Hetero Compounds. XVIII. Synthesis of the 11,13,15-Triazasteroidal Skeleton with an Oxygen Function at C-17
AU - Hirota, Takashi
AU - Katsuta, Kimiko
AU - Kawanishi, Keiko
AU - Namba, Tetsuto
AU - Sasaki, Kenji
AU - Hayakawa, Shōhei
PY - 1985/1/1
Y1 - 1985/1/1
N2 - N-(5,6-Dihydro-4-benzo[h]quinazolinyl)amino acids (III and VII) were synthesized by condensation of 4-chloro-5,6-dihydrobenzo[h]quinazoline (II) with several amino acids and were cyclized to 4,5-dihydrobenz[h]imidazo[1,2-c]quinazoline derivatives, i.e.,11,13,15-triazasteroidal compounds (IV, V, VI, VIII, and IX) using phosphoryl chloride or acetic anhydride. An oxygen function could be introduced at C-l of 4,5-dihydrobenz[h]imidazo[l,2-c]quinazoline, i.e., C-17 of the 11,13,15-triazasteroidal compounds.
AB - N-(5,6-Dihydro-4-benzo[h]quinazolinyl)amino acids (III and VII) were synthesized by condensation of 4-chloro-5,6-dihydrobenzo[h]quinazoline (II) with several amino acids and were cyclized to 4,5-dihydrobenz[h]imidazo[1,2-c]quinazoline derivatives, i.e.,11,13,15-triazasteroidal compounds (IV, V, VI, VIII, and IX) using phosphoryl chloride or acetic anhydride. An oxygen function could be introduced at C-l of 4,5-dihydrobenz[h]imidazo[l,2-c]quinazoline, i.e., C-17 of the 11,13,15-triazasteroidal compounds.
KW - N-(4-benzo[h]quinazolinyl)amino acid
KW - acetic anhydride
KW - amino acid
KW - benz[h]imidazol[1,2-c]quinazoline
KW - cyclization acetylation
KW - phosphoryl chloride
UR - http://www.scopus.com/inward/record.url?scp=0021922067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021922067&partnerID=8YFLogxK
U2 - 10.1248/cpb.33.30
DO - 10.1248/cpb.33.30
M3 - Article
AN - SCOPUS:0021922067
SN - 0009-2363
VL - 33
SP - 30
EP - 36
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 1
ER -