TY - JOUR
T1 - Polycyclic N-Hetero Compounds. XXIII. Synthesis and Antidepressive Activity of 4-Substituted 5,6-Dihydrobenzo[h]quinazolines
AU - Hirota, Takashi
AU - Kawanishi, Keiko
AU - Sasaki, Kenji
AU - Namba, Tetsuto
PY - 1986/1/1
Y1 - 1986/1/1
N2 - 4-Alkylamino-5,6-dihydrobenzo[h]quinazolines (IIIa—k) were synthesized by the reaction of 4-chloro-5,6-dihydrobenzo[h]quinazoline (IIc) with primary alkylamines. Screening of 4-amino-(IIa), 4-hydroxy- (IIb), and 4-(2-hydroxyethylamino)-5,6-dihydrobenzo[h]quinazoline (lid), as well as IIc and IIIa—k, for antireserpine action indicated that lid, IIIa, and IIIh exhibited effective antidepressant activity.
AB - 4-Alkylamino-5,6-dihydrobenzo[h]quinazolines (IIIa—k) were synthesized by the reaction of 4-chloro-5,6-dihydrobenzo[h]quinazoline (IIc) with primary alkylamines. Screening of 4-amino-(IIa), 4-hydroxy- (IIb), and 4-(2-hydroxyethylamino)-5,6-dihydrobenzo[h]quinazoline (lid), as well as IIc and IIIa—k, for antireserpine action indicated that lid, IIIa, and IIIh exhibited effective antidepressant activity.
KW - 4-alkylaminobenzo[h]quinazoline
KW - antidepressive activity
KW - antireserpine activity
KW - benzo[h]quinazoline
KW - primary alkylamine
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U2 - 10.1248/cpb.34.3011
DO - 10.1248/cpb.34.3011
M3 - Article
C2 - 3769105
AN - SCOPUS:0022465393
SN - 0009-2363
VL - 34
SP - 3011
EP - 3014
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 7
ER -