TY - JOUR
T1 - Polycyclic N-heterocyclic compounds, part 71
T2 - Synthesis and bronchodilator evaluation of 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines and related compounds
AU - Okuda, Kensuke
AU - Matsushita, Tetsuo
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Several 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride-induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3-isobutyl-1-methylxanthine.
AB - Several 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride-induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3-isobutyl-1-methylxanthine.
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U2 - 10.1002/jhet.846
DO - 10.1002/jhet.846
M3 - Article
AN - SCOPUS:84866242970
SN - 0022-152X
VL - 49
SP - 742
EP - 747
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 4
ER -