TY - JOUR
T1 - Polycyclic N-heterocyclic compounds. Part 79
T2 - Synthesis of 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines as potential antiplatelet aggregators
AU - Okuda, Kensuke
AU - Hirota, Takashi
AU - Sasaki, Kenji
PY - 2014/11/24
Y1 - 2014/11/24
N2 - Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.
AB - Libraries of tricyclic 2-substituted 4-alkylamino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines were synthesized as part of our research to develop new effective antiplatelet drugs. Several alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin.
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U2 - 10.1002/jhet.1714
DO - 10.1002/jhet.1714
M3 - Article
AN - SCOPUS:84915737377
SN - 0022-152X
VL - 51
SP - 1607
EP - 1614
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 6
ER -