Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia

Kenji Sasaki; Takashi Hirota; Yuichi Arimoto; Yoshiko Satoh; Hiromi Ohtomo; Taiji Nakayama

doi:10.1002/jhet.5570270648

Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia

Kenji Sasaki, Takashi Hirota, Yuichi Arimoto, Yoshiko Satoh, Hiromi Ohtomo, Taiji Nakayama

Research output: Contribution to journal › Article › peer-review

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Abstract

Various 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d]pyrimidines were synthesized by the reaction of 4‐chloro‐6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d]pyrimidine with amines. Their inhibitory activities against collagen‐induced platelet aggregation and also against reserpine‐induced hypothermia in mice were investigated.

Original language	English
Pages (from-to)	1771-1776
Number of pages	6
Journal	Journal of Heterocyclic Chemistry
Volume	27
Issue number	6
DOIs	https://doi.org/10.1002/jhet.5570270648
Publication status	Published - Jan 1 1990

ASJC Scopus subject areas

Organic Chemistry

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Sasaki, K., Hirota, T., Arimoto, Y., Satoh, Y., Ohtomo, H., & Nakayama, T. (1990). Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia. Journal of Heterocyclic Chemistry, 27(6), 1771-1776. https://doi.org/10.1002/jhet.5570270648

Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia. / Sasaki, Kenji; Hirota, Takashi; Arimoto, Yuichi et al.
In: Journal of Heterocyclic Chemistry, Vol. 27, No. 6, 01.01.1990, p. 1771-1776.

Research output: Contribution to journal › Article › peer-review

Sasaki, K, Hirota, T, Arimoto, Y, Satoh, Y, Ohtomo, H & Nakayama, T 1990, 'Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia', Journal of Heterocyclic Chemistry, vol. 27, no. 6, pp. 1771-1776. https://doi.org/10.1002/jhet.5570270648

Sasaki K, Hirota T, Arimoto Y, Satoh Y, Ohtomo H, Nakayama T. Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia. Journal of Heterocyclic Chemistry. 1990 Jan 1;27(6):1771-1776. doi: 10.1002/jhet.5570270648

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Polycyclic N‐hetero compounds. XXXIII. Syntheses of 4‐substituted 6,7‐dihydro‐5H‐benzo[6,7]‐cyclohepta[1,2‐d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine‐induced hypothermia

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