TY - JOUR
T1 - Polycyclic N‐hetero compounds. XXXV. Syntheses and anti‐platelet aggregation activity of 5,6‐Dihydro‐4H‐benzo[3,4]cyclohept[1,2‐e]imidazo[1,2‐c]pyrimidines with an oxygen function at the 1‐position
AU - Sasaki, Kenji
AU - Sekiya, Yuhki
AU - Nagamatsu, Tomohisa
AU - Ohtomo, Hiromi
AU - Nakayama, Taiji
AU - Hirota, Takashi
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Various 6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d][pyrimidines bearing amino acid group at the 4‐position of the skeleton were synthesized by the reaction of 4‐chloro‐6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d]‐pyrimidine with some amino acid, which were cyclized to 5,6‐dihydro‐4H‐benzo[3,4]cyclohept[1,2‐e]imidazo‐[1,2‐c]pyrimidines, corresponding to B‐homo‐11,13,15‐triazasteroids. Their inhibitory activities against platelet aggregation induced by collagen were also investigated.
AB - Various 6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d][pyrimidines bearing amino acid group at the 4‐position of the skeleton were synthesized by the reaction of 4‐chloro‐6,7‐dihydro‐5H‐benzo[6,7]cyclohepta[1,2‐d]‐pyrimidine with some amino acid, which were cyclized to 5,6‐dihydro‐4H‐benzo[3,4]cyclohept[1,2‐e]imidazo‐[1,2‐c]pyrimidines, corresponding to B‐homo‐11,13,15‐triazasteroids. Their inhibitory activities against platelet aggregation induced by collagen were also investigated.
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U2 - 10.1002/jhet.5570280258
DO - 10.1002/jhet.5570280258
M3 - Article
AN - SCOPUS:0025904894
SN - 0022-152X
VL - 28
SP - 503
EP - 507
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 2
ER -