Polymorphisms detected in actin-related sequences of rats (Rattus norvegicus).

T. Kunieda, H. Ikadai, M. Matsui, N. Nomura, R. Ishizaki, T. Imamichi

Research output: Contribution to journalArticlepeer-review


Southern blot hybridization of EcoRI digests of DNAs from 13 rat strains using human cardiac actin gene as a probe revealed polymorphisms in actin-related sequences of rats. EcoRI fragments of 11 kb, 7 kb, 6 kb, 5 kb, 4.5 kb and 4 kb detected in several strains were absent in the remaining strains. The presence of these fragments was suggested to be due to presence of extra sequences homologous to the actin genes, such as processed pseudogenes, in the particular strains. The 13 strains were assigned to each of 7 specific patterns of the polymorphic EcoRI fragments. It was concluded that the polymorphisms of actin-related sequences should be useful for genetic monitoring of laboratory rats.

Original languageEnglish
Pages (from-to)307-310
Number of pages4
JournalJikken dobutsu. Experimental animals
Issue number2
Publication statusPublished - Apr 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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