TY - JOUR
T1 - Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines
AU - Ito, Hideyuki
AU - Kobayashi, Eri
AU - Takamatsu, Yoshie
AU - Li, Shu Hua
AU - Hatano, Tsutomu
AU - Sakagami, Hiroshi
AU - Kusama, Kaoru
AU - Satoh, Kazue
AU - Sugita, Daigo
AU - Shimura, Susumu
AU - Itoh, Yoshio
AU - Yoshida, Takashi
PY - 2000/5
Y1 - 2000/5
N2 - Three new flavonoid glycosides, together with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- and (2R)-naringenin 8-C-α-L-rhamnopyranosyl-(1→2)-β-D- glucopyranosides, and cinchonain Id 7-O-β-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in the water-soluble portion of the extract was characterized as a procyanidin oligomer mixture mainly composed of undecameric procyanidin. These polyphenols have also been assessed for cytotoxic activity against two human oral tumor (human squamous cell carcinoma and human salivary gland tumor) cell lines. Selective cytotoxicity of the procyanidin oligomer between tumor and normal gingival fibroblast cells, and its possible mechanism, were also described.
AB - Three new flavonoid glycosides, together with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- and (2R)-naringenin 8-C-α-L-rhamnopyranosyl-(1→2)-β-D- glucopyranosides, and cinchonain Id 7-O-β-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in the water-soluble portion of the extract was characterized as a procyanidin oligomer mixture mainly composed of undecameric procyanidin. These polyphenols have also been assessed for cytotoxic activity against two human oral tumor (human squamous cell carcinoma and human salivary gland tumor) cell lines. Selective cytotoxicity of the procyanidin oligomer between tumor and normal gingival fibroblast cells, and its possible mechanism, were also described.
KW - Cinchonain Id 7-O-β-D- glucopyranoside
KW - Eriobotrya japonica
KW - Human oral tumor cell line
KW - Naringenin 8-C-α-L-rhamnopyranosyl(1→2)-β-D- glucopyranoside
KW - Rosaceae
KW - Undecameric procyanidin
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UR - http://www.scopus.com/inward/citedby.url?scp=18744430091&partnerID=8YFLogxK
U2 - 10.1248/cpb.48.687
DO - 10.1248/cpb.48.687
M3 - Article
C2 - 10823708
AN - SCOPUS:18744430091
SN - 0009-2363
VL - 48
SP - 687
EP - 693
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 5
ER -