Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes

Takashi Uehara; Masayuki Kaneko; Shinji Tanaka; Yasunobu Okuma; Yasuyuki Nomura

doi:10.1016/S0006-8993(99)01178-6

Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes

Takashi Uehara, Masayuki Kaneko, Shinji Tanaka, Yasunobu Okuma, Yasuyuki Nomura

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.

Original language	English
Pages (from-to)	226-230
Number of pages	5
Journal	Brain Research
Volume	823
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01178-6
Publication status	Published - Mar 27 1999
Externally published	Yes

Keywords

Astrocyte
HSP70
Hypoxia
Ischemia
p38 MAP kinase

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01178-6

Cite this

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abstract = "The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.",

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AU - Uehara, Takashi

AU - Kaneko, Masayuki

AU - Tanaka, Shinji

AU - Okuma, Yasunobu

AU - Nomura, Yasuyuki

PY - 1999/3/27

Y1 - 1999/3/27

N2 - The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.

AB - The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.

KW - Astrocyte

KW - HSP70

KW - Hypoxia

KW - Ischemia

KW - p38 MAP kinase

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JO - Brain Research

JF - Brain Research

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Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes

Abstract

Keywords

ASJC Scopus subject areas

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