Potency of water extracts of rhizopus oryzae on the salmonella infection rat

Takehito Suzuki, Hideo Fukuoka, Setsuo Ushikoshi, Hidetoshi Morita

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Rhizopus oryzae U-1 water extract (ROU-we) was administered orally to rats at 10 mg/kg body weight for 9 days. Salmonella enteritidts was inoculated at a dose of 109CFU/animal. The following protective effects of ROU-we against infection were examined: cell counts of Salmonella in organs of infected rats (liver, spleen, and mesenteric lymph nodes); phagocytic capacity of collected peripheral monocytes and peritoneal macrophages; cell counts of respective helper T-cell subclasses (Th0, Th1, and Th2); and the leukocyte percentage in peripheral blood. The Salmonella cell count in the liver of the ROU-we group decreased significantly compared to that of the control group and the peripheral monocytes' phagocytic capacity increased 4.5-fold. Moreover, the ROU-we group's Th1 response was higher than the infected control group. However, the healthy control group and the ROU-we group showed similar Th1/Th2 balance and cell count tendencies. These results suggest that ROU-we activated peripheral monocytes and improved Th1/Th2 balance, thereby strengthening immunity against Salmonella infection.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalFood Science and Technology Research
Issue number3
Publication statusPublished - Aug 2007
Externally publishedYes


  • Immunostimulative effect
  • Infection
  • Rhizopus oryzae
  • Salmonella enteritidis
  • Th1/Th2

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing


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