Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Hiroyuki Miyachi; Akihiko Azuma; Takuya Kitamoto; Kozue Hayashi; Shigeaki Kato; Masafumi Koga; Bunzo Sato; Yuichi Hashimoto

doi:10.1016/S0960-894X(97)00249-7

Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Hiroyuki Miyachi, Akihiko Azuma, Takuya Kitamoto, Kozue Hayashi, Shigeaki Kato, Masafumi Koga, Bunzo Sato, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

Original language	English
Pages (from-to)	1483-1488
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(97)00249-7
Publication status	Published - Jun 3 1997

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00249-7

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title = "Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton",

abstract = "Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.",

author = "Hiroyuki Miyachi and Akihiko Azuma and Takuya Kitamoto and Kozue Hayashi and Shigeaki Kato and Masafumi Koga and Bunzo Sato and Yuichi Hashimoto",

note = "Funding Information: This work was partially supported by a Grant-in Aid for Scientific.",

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T1 - Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

AU - Miyachi, Hiroyuki

AU - Azuma, Akihiko

AU - Kitamoto, Takuya

AU - Hayashi, Kozue

AU - Kato, Shigeaki

AU - Koga, Masafumi

AU - Sato, Bunzo

AU - Hashimoto, Yuichi

N1 - Funding Information: This work was partially supported by a Grant-in Aid for Scientific.

PY - 1997/6/3

Y1 - 1997/6/3

N2 - Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

AB - Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgen-dependent clonal cell line SC-3. Some compounds showed very potent androgen-antagonistic activity.

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U2 - 10.1016/S0960-894X(97)00249-7

DO - 10.1016/S0960-894X(97)00249-7

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 11

ER -

Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Abstract

ASJC Scopus subject areas

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