Practical synthesis of dirhodium(II) tetrakis[N-phthaloyl-(S)- tertleucinate]

Hideyuki Tsutsui; Takumi Abe; Seiichi Nakamura; Masahiro Anada; Shunichi Hashimoto

doi:10.1248/cpb.53.1366

Practical synthesis of dirhodium(II) tetrakis[N-phthaloyl-(S)- tertleucinate]

Hideyuki Tsutsui, Takumi Abe, Seiichi Nakamura, Masahiro Anada, Shunichi Hashimoto

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh₂(S-PTTL)₄, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

Original language	English
Pages (from-to)	1366-1368
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	10
DOIs	https://doi.org/10.1248/cpb.53.1366
Publication status	Published - Oct 2005
Externally published	Yes

Keywords

Chiral catalyst
Dirhodium(II) carboxylate
N-phthaloylation
tert-leucine

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.53.1366

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abstract = "An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.",

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author = "Hideyuki Tsutsui and Takumi Abe and Seiichi Nakamura and Masahiro Anada and Shunichi Hashimoto",

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AU - Abe, Takumi

AU - Nakamura, Seiichi

AU - Anada, Masahiro

AU - Hashimoto, Shunichi

PY - 2005/10

Y1 - 2005/10

N2 - An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

AB - An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

KW - Chiral catalyst

KW - Dirhodium(II) carboxylate

KW - N-phthaloylation

KW - tert-leucine

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Practical synthesis of dirhodium(II) tetrakis[N-phthaloyl-(S)- tertleucinate]

Abstract

Keywords

ASJC Scopus subject areas

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